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当前位置: 首页 > 产品中心 > DNA_polymerase > 信号化学/RIPK1,有效/5 ug/R07M-11G-05
商品详细信号化学/RIPK1,有效/5 ug/R07M-11G-05
信号化学/RIPK1,有效/5 ug/R07M-11G-05
信号化学/RIPK1,有效/5 ug/R07M-11G-05
商品编号: R07M-11G-05
品牌: Signalchem inc
市场价: ¥8700.00
美元价: 5220.00
产地: 美国(厂家直采)
公司:
产品分类: DNA聚合酶
公司分类: DNA_polymerase
联系Q Q: 3392242852
电话号码: 4000-520-616
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商品介绍

Overview:

RIPK1 or Receptor Interacting Protein Kinase 1 is a serine/threonine kinase that was originally identified as interacting with the cytoplasmic domain of FAS. RIPK1 has been deemed as an important element in the signal transduction machinery that mediates programmed cell death. RIPK1 has been shown to interact with TRADD, TRAF1 TRAF2 and TRAF3 and TRADD can act as an adaptor protein to recruit RIPK1 to the TNFR1 complex in a TNF-dependent process (1). TNFα is capable of activating the noncanonical NF-κB pathway, but this activation of this pathway is negatively regulated by RIPK1 (2).

Gene Aliases:

D330015H01Rik; Rinp; RIP; Rip1

Genbank Number:

NM_009068

References:

1. Hsu, H. et al: TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex. Immunity 4: 387-396, 1996.
2. Kim, J Y. et al: TNFα induced noncanonical NF-κB activation is attenuated by RIP1 through stabilization of TRAF2. J Cell Sci. 2011 Feb 15;124(Pt 4):647-56.

品牌介绍
SignalChem 公司生产和销售创新性的细胞信号研究相关产品。公司专注于生产高纯度的活性重组蛋白,产品广泛应用于基础生物学和药物研究。
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