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商品详细Signalchem/ROS1,有源/10 ug/R14-11BG-10
Signalchem/ROS1,有源/10 ug/R14-11BG-10
Signalchem/ROS1,有源/10 ug/R14-11BG-10
商品编号: R14-11BG-10
品牌: Signalchem inc
市场价: ¥6500.00
美元价: 3900.00
产地: 美国(厂家直采)
公司:
产品分类: 聚合物
公司分类: juhewu
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商品介绍

Overview:

ROS1 is a proto-oncogene and member of the sevenless subfamily of tyrosine kinase insulin receptor genes. ROS1 is highly-expressed in a variety of tumor cell lines and functions as a growth or differentiation factor receptor. The FIG gene can fuse with the ROS1 gene in glioblastoma cell lines (1). The resulting ROS1/FIG fusion protein is a constitutively activated tyrosine kinase. Direct interaction of ROS1 and the phosphatase SHP-1 can lead to efficient downregulation of ROS1-mediated signaling (2). Binding sites in the ROS1 cytoplasmic domain display high affinity binding to the SHP-1 N-terminal SH2 domain.

Gene Aliases:

c-ros-1; MCF3; ROS

Genbank Number:

NM_002944

References:

1. Charest, A. et al: Fusion of FIG to the receptor tyrosine kinase ROS in a glioblastoma with an interstitial del(6)(q21q21). Genes Chromosomes Cancer 37: 58-71, 2003.2. Biscup, C. et al: Visualization of SHP-1-target interaction. J Cell Sci. 2004 Oct 1;117(Pt 21):5165-78.

品牌介绍
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