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当前位置: 首页 > 产品中心 > juhewu > Signalchem/PFKFB3(S269A),有源/10 ug/P323-10BG-10
商品详细Signalchem/PFKFB3(S269A),有源/10 ug/P323-10BG-10
Signalchem/PFKFB3(S269A),有源/10 ug/P323-10BG-10
Signalchem/PFKFB3(S269A),有源/10 ug/P323-10BG-10
商品编号: P323-10BG-10
品牌: Signalchem inc
市场价: ¥7600.00
美元价: 4560.00
产地: 美国(厂家直采)
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产品分类: 聚合物
公司分类: juhewu
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商品介绍

Overview:

PFKFB3 or 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 is a potent activator of a key regulatory enzyme in the glycolysis pathway called phosphofructokinase. Phosphofructokinase regulates the steady-state concentration of fructose-2,6-bisphosphate, a potent activator of key regulatory enzyme of the glycolysis pathway. PFKFB3 is bifunctional, although the phosphatase activity is low due to a mutation in an active site which can be upregulated after phosphorylation by protein kinases (1). PFKFB3 may be responsible for sustaining the high glycolytic flux of rapidly proliferating leukemia cells and may represent a molecular target for chemotherapeutic intervention (2).

Gene Aliases:

IPFK2; PFK2

Genbank Number:

NM_004566

References:

1. Sakakibara, R.et.al: Characterization of a human placental fructose-6-phosphate,2-kinase/fructose-2,6-bisphosphatase. J. Biochem. 122: 122-128, 1997.2. Chesney, J. et.al: An inducible gene product for 6-phosphofructo-2-kinase with an AU-rich instability element: role in tumor cell glycolysis and the Warburg effect. Proc. Nat. Acad. Sci. 96: 3047-3052, 1999.

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