4000-520-616
欢迎来到免疫在线!(蚂蚁淘生物旗下平台)  请登录 |  免费注册 |  询价篮
主营:主营:活性激酶,信号蛋白,激酶抗体,非活性激酶,活性磷酸酶,生物相关激酶和多肽底物
咨询热线电话
4000-520-616
当前位置: 首页 > 产品中心 > juhewu > Signalchem/PTEN, Active/10 ug/T03-20H-10
商品详细Signalchem/PTEN, Active/10 ug/T03-20H-10
Signalchem/PTEN, Active/10 ug/T03-20H-10
Signalchem/PTEN, Active/10 ug/T03-20H-10
商品编号: T03-20H-10
品牌: Signalchem inc
市场价: ¥6500.00
美元价: 3900.00
产地: 美国(厂家直采)
公司:
产品分类: 聚合物
公司分类: juhewu
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

Overview:

PTEN (phosphatase and tensin homolog) is a tumor suppressor that is frequently mutated in a large number of cancers (1). PTEN has phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity and contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, PTEN preferentially dephosphorylates phosphoinositide substrates and is responsible for negatively regulating the intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells. PTEN functions as a tumor suppressor by negatively regulating the PI3K/AKT signaling pathway (2).

Gene Aliases:

ZS; DEC; GLM2; MHAM; TEP1; MMAC1; PTEN1; 10q23del; MGC11227

Genbank Number:

NM_000314

References:

1. Butler, M.G. et al: Subset of individuals with autism spectrum disorders and extreme macrocephaly associated with germline PTEN tumour suppressor gene mutations. J. Med. Genet. 2005;42(4):318-21.2. Steck, P.A. et aal: Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat. Genet. 1997; 15(4):356-62

品牌介绍
SignalChem 公司生产和销售创新性的细胞信号研究相关产品。公司专注于生产高纯度的活性重组蛋白,产品广泛应用于基础生物学和药物研究。
联络我们
服务热线:4000-520-616
(限工作日9:00-18:00)
QQ :1570468124
手机:18915418616