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商品详细Signalchem/PAD4, Active/10 ug/P312-310DG-10
Signalchem/PAD4, Active/10 ug/P312-310DG-10
Signalchem/PAD4, Active/10 ug/P312-310DG-10
商品编号: P312-310DG-10
品牌: Signalchem inc
市场价: ¥6500.00
美元价: 3900.00
产地: 美国(厂家直采)
公司:
产品分类: 聚合物
公司分类: juhewu
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

Overview:

PAD4 is a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions (1). PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps (NETs) (2). PAD4 play a role in granulocyte and macrophage development leading to inflammation and immune response. PAD4 also mediates the gene expression by regulating arginine methylation and citrullination in histones (3).

Gene Aliases:

PADI4; PAD; PDI4; PDI5

Genbank Number:

BC025718

References:

1. Nakashima, K. et.al: Molecular characterization of peptidylarginine deiminase in HL-60 cells induced by retinoic acid and 1-alpha,25-dihydroxyvitamin D(3). J. Biol. Chem. 274: 27786-27792, 1999.2. Li, P.et.al: PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps. J. Exp. Med. 207: 1853-1862, 2010.3. Wang, Y. et.al: Human PAD4 regulates histone arginine methylation levels via demethylimination. Science 306: 279-283, 2004.

品牌介绍
SignalChem 公司生产和销售创新性的细胞信号研究相关产品。公司专注于生产高纯度的活性重组蛋白,产品广泛应用于基础生物学和药物研究。
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