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商品详细Signalchem/Hydroxychloroquine/50 mg/T860-905-50
Signalchem/Hydroxychloroquine/50 mg/T860-905-50
Signalchem/Hydroxychloroquine/50 mg/T860-905-50
商品编号: T860-905-50
品牌: Signalchem inc
市场价: ¥1100.00
美元价: 660.00
产地: 美国(厂家直采)
公司:
产品分类: 聚合物
公司分类: juhewu
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

Overview:

**COVID-19 RELATION**Hydroxychloroquine sulfate is a synthetic version of quinolyl and is a disease-modifying anti-rheumatic drug. The compound acts on the novel SARs-Cov-2 through different mechanisms such as altering the pH at the cell surface, hence inhibiting the viral fusion to the cell membrane receptors, inhibiting nucleic acid replication, by inducing glycosylation of viral proteins. these mechanisms ultimately stopping viral replication and viral infection achieving its antiviral effects. Currently, this compound is being scientifically scrutinized globally for its role against the Sars-Cov-2 virus.** A lysosomotropic agent which inhibits autophagy and triggers apoptosis in a variety of cell types (1,2). Augments the anticancer activity of DNA-damaging chemotherapy (3). Anti-inflammatory activity. Decreases cell surface expression of TNFα receptors in U937 cells (4). Has been used to treat alopecia successfully (5). Clinically useful antimalaria agent. Cell permeable and active in vivo.

References:

1. P Boya et al. Mol. Cell Biol. 2005 25:10252. X Xie et al. PLoS One 2013 8:e550963. Y Pan et al. Clin. Cancer Res. 2011 150:32484. JY Jeong et al. Immunology 2002 105:835. F Stephan et al. J. Am. Acad. Dermatol. 2013 68:1048

品牌介绍
SignalChem 公司生产和销售创新性的细胞信号研究相关产品。公司专注于生产高纯度的活性重组蛋白,产品广泛应用于基础生物学和药物研究。
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