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商品详细Signalchem/Mycophenolic acid/500 mg/I23-905-500
Signalchem/Mycophenolic acid/500 mg/I23-905-500
Signalchem/Mycophenolic acid/500 mg/I23-905-500
商品编号: I23-905-500
品牌: Signalchem inc
市场价: ¥2300.00
美元价: 1380.00
产地: 美国(厂家直采)
公司:
产品分类: 聚合物
公司分类: juhewu
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

Overview:

**COVID-19 RELATION**Mycophenolic acid (MPA), an immunosuppressant, is an uncompetitive and reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH).The immunomodulator has been actively studied for its in vitro antiviral potency against a broad family of viruses including seasonal influenza and MERS and has shown a positive effect on improving the state of patients suffering from severe pneumonia caused by these viruses. As a potent IMPDH inhibitor, scientists are studying its antiviral role against the SARS-COV-2 virus, as studies suggest that the novel virus interacts with cellular IMPDH2 utilizing the Nsp14 viral protein.**Immunomodulator (1). Blocks the biosynthesis of guanine nucleotides via inhibition of inosine 5’-monophosphate dehydrogenase which suppresses the production of proinflammatory cytokines, nitric oxide and LDH in macrophages (2,3). Inhibits IL-2-dependent T cell proliferation (4).

References:

1. EM Eugui et al. Scand. J. Immunol. 1991 33:1612. CA Jonsson et al. Cell. Immunol. 2002 216:933. AC Allison et al. Ann. NY Acad. Sci. 1993 696:634. J Quemeneur et al. J. Immunol. 2002 169:2747

品牌介绍
SignalChem 公司生产和销售创新性的细胞信号研究相关产品。公司专注于生产高纯度的活性重组蛋白,产品广泛应用于基础生物学和药物研究。
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