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商品详细Signalchem/盐酸维拉帕米/5000 mg/V114-908-5000
Signalchem/盐酸维拉帕米/5000 mg/V114-908-5000
Signalchem/盐酸维拉帕米/5000 mg/V114-908-5000
商品编号: V114-908-5000
品牌: Signalchem inc
市场价: ¥1700.00
美元价: 1020.00
产地: 美国(厂家直采)
公司:
产品分类: 聚合物
公司分类: juhewu
联系Q Q: 3392242852
电话号码: 4000-520-616
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商品介绍

Overview:

**COVID-19 RELATION**Verapamil is a phenylalkylamine calcium channel blocking compound, which inhibits the transmembrane influx of calcium ions into the cells. The inhibitory potential of verapamil halting the replication of many viruses such as influenza A, MARV, Ebola virus has been well documented. Verapamil also targets the Multidrug resistance-associated protein 1 (MRP1), which studies have shown, interacts with the SARS-CoV-2 Orf9c protein. Breaking this link can prove to be a successful therapeutic intervention against the SARSCOV2 virus. **L-type calcium channel blocker (1). Clinically useful for the treatment of hypertension and coronary artery disease (2). Binds to and inhibits P-glycoprotein and reverses multidrug resistance in multidrug-resistant CHO cells (3,4). Induces autophagy (5).

References:

1. L Lacinova et al. J. Pharmacol. Exp. Ther. 1995 274:542. RN Brogdan and P Benfield Drugs 1996 51:792 3. AR Safa et al. J. Biol. Chem. 1987 262:78844. M Chatterjee et al. Cancer Res. 1990 50:28185. A Fleming Nat. Chem. Biol. 2011 7:9

品牌介绍
SignalChem 公司生产和销售创新性的细胞信号研究相关产品。公司专注于生产高纯度的活性重组蛋白,产品广泛应用于基础生物学和药物研究。
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