Overview:
BMP2KorBonemorphogenicprotein2inducIBLekinaseisthehumanhomologofmouseBMP-2-induciblekinasewhichplaysakeyroleinskeletaldevelopmentandpatterning.BMP2Kisaserine/threonineproteinkinasewhichcontainsanuclearlocalizationsignalandplaysaregulatoryroleinattenuatingtheprogramofosteoblastdifferentiation.BMP2Kgeneisstronglycorrelatedwithhighmyopiaandmaycontributetoageneticriskfactorforhighdegreesofmyopicpathogenesis(1).BMP-2expressionissuppressedbyanEP4receptorantagoNISTandPGE2producedbyCOX-2increasesBMP-2expressionviabindingtheEP4receptor(2).
GeneAliases:
BIKE;4933417M22Rik;AA673486;AV128808
GenbankNumber:
NM_080708
References:
1.LiuHP.et.al:AnovelgeneticvariantofBMP2Kcontributestohighmyopia.JClinLabAnal.2009;23(6):362-7.2.ArikawaT.et.al:Regulationofbonemorphogeneticprotein-2expressionbyendogenousprostaglandinE2inhumanmesenchymalstemcells.JCellPhysiol.2004Sep;200(3):400-6.
