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商品详细Signalchem/ERN1(R727A R728A),有源/10 ug/E31-12DG-10
Signalchem/ERN1(R727A R728A),有源/10 ug/E31-12DG-10
Signalchem/ERN1(R727A R728A),有源/10 ug/E31-12DG-10
商品编号: E31-12DG-10
品牌: Signalchem inc
市场价: ¥6500.00
美元价: 3900.00
产地: 美国(厂家直采)
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产品分类: 聚合物
公司分类: juhewu
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商品介绍

Overview:

ERN1 or endoplasmic reticulum to nucleus signaling 1 is the ER to nucleus signaling 1 protein, a human homologue of the yeast Ire1 gene product which possesses intrinsic kinase activity and an endoribonuclease activity and it is important in endoplasmic reticulum-based stress signals. ERN1 controls IRE1 proteolysis in mammalian cells (1). The activation of ERN1 through oligomerization expands the mechanistic repertoire of kinase-based signaling receptors. ERNI has a critical function in extraembryonic cells that is essential for fetal viability (2).

Gene Aliases:

hIRE1p; IRE1; IRE1A; IRE1P

Genbank Number:

NM_001433

References:

1. Niwa, M.et.al: A role for presenilin-1 in nuclear accumulation of Ire1 fragments and induction of the mammalian unfolded protein response. Cell 99: 691-702, 1999.2. Iwawaki, T.et.al: Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability. Proc. Nat. Acad. Sci. 106: 16657-16662, 2009.

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SignalChem 公司生产和销售创新性的细胞信号研究相关产品。公司专注于生产高纯度的活性重组蛋白,产品广泛应用于基础生物学和药物研究。
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