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商品详细Signalchem/BRAF(D594G)蛋白质/5 ug/B08-12MG-05
Signalchem/BRAF(D594G)蛋白质/5 ug/B08-12MG-05
Signalchem/BRAF(D594G)蛋白质/5 ug/B08-12MG-05
商品编号: B08-12MG-05
品牌: Signalchem inc
市场价: ¥4520.00
美元价: 2712.00
产地: 美国(厂家直采)
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产品分类: 聚合物
公司分类: juhewu
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商品介绍

Overview:

BRAF is a member of the RAF family that is activated by members of the Ras family upon growth factor-induced stimulation. Protein Ras can induce heterodimerization of cRaf and BRAF and this may explain the observed cooperativity of cRaf and BRAF in cells responding to growth factor signals (1). Activating mutations in the BRAF gene are present in a large percentage of human malignant melanomas and in a proportion of colon cancers. The vast majority of these mutations result in a valine to glutamic acid change at residue 599 within the activation segment of BRAF (2).

Gene Aliases:

BRAF1, RAFB1, B-raf, B-raf 1, MGC126806, MGC138284

Genbank Number:

NM_004333

References:

1. Weber, C K. et al: Protein Ras induces heterodimerization of cRaf and BRaf. Cancer Res. 2001 May 1;61(9):3595-8.2. Mercer, K E. et al: Raf proteins and cancer: B-Raf is identified as a mutational target. Biochim Biophys Acta. 2003 Jun 5;1653(1):25-40.

品牌介绍
SignalChem 公司生产和销售创新性的细胞信号研究相关产品。公司专注于生产高纯度的活性重组蛋白,产品广泛应用于基础生物学和药物研究。
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