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商品详细Signalchem/DLK,有源/5 ug/M20-11G-05
Signalchem/DLK,有源/5 ug/M20-11G-05
Signalchem/DLK,有源/5 ug/M20-11G-05
商品编号: M20-11G-05
品牌: Signalchem inc
市场价: ¥4520.00
美元价: 2712.00
产地: 美国(厂家直采)
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产品分类: 聚合物
公司分类: juhewu
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商品介绍

Overview:

DLK or mitogen-activated protein kinase kinase kinase 12 is a transmembrane protein containing six epidermal growth factor repeats and is a serine/threonine protein kinase. DLK is involved in the differentiation of several cell types, including adipocytes. DLK plays a role of a tumor suppressor protein and is predominately expressed in neuronal cells. DLK as an activator of the Jnk pathway. Overexpression of DLK results in activation of Jnk1 and the accumulation of a hyperphosphorylated form of c-Jun (1). Postnatal loss of DLK in stem cells and niche astrocytes has been shown to regulate neurogenesis (2).

Gene Aliases:

MAP3K12; MUK; ZPK; ZPKP1; MEKK12

Genbank Number:

NM_006301

References:

1. Hirai, S. et al: Activation of the JNK pathway by distantly related protein kinases, MEKK and MUK. Oncogene 12: 641-650, 1996.2. Ferron, S. R.et.al: Postnatal loss of Dlk1 imprinting in stem cells and niche astrocytes regulates neurogenesis. Nature 475: 381-385, 2011.

品牌介绍
SignalChem 公司生产和销售创新性的细胞信号研究相关产品。公司专注于生产高纯度的活性重组蛋白,产品广泛应用于基础生物学和药物研究。
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