Overview:

Diacylglycerol kinase delta (DGKD) is a member of DGK family type II which have a pleckstrin homology domain instead of the EF-hand motif in addition to two cysteine-rich regions (C1 domain) in the regulatory domain. These enzymes catalyze the phosphorylation of diacylglycerol, a fundamental lipid second messenger that activates numerous proteins such as protein kinase C isoforms and RAS guanyl nucleotide-releasing proteins and some transient receptor potential channels.(1) DGK delta is involved in cell proliferation and glucose metabolism, and has been associated with certain cancers, diabetes and epilepsy.(2)

Gene Aliases:

DGKdelta, DGKD-2, DAGKdelta

Genbank Number:

NM_003648

References:

1. Sakane, F. et al. (1997) Diacylglycerol kinase J. Biol. Chem. 29, 1139-1143.2. Sakai, H. et al. (2012). Recent progress on type II diacylglycerol kinases: the physiological functions of diacylglycerol kinase, δ, η and κ their involvement in disease. J Biochem. 152(5):397-406.