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商品详细Signalchem/DNAJB1-PRKACA,现行/10 ug/P51-19BG-10
Signalchem/DNAJB1-PRKACA,现行/10 ug/P51-19BG-10
Signalchem/DNAJB1-PRKACA,现行/10 ug/P51-19BG-10
商品编号: P51-19BG-10
品牌: Signalchem inc
市场价: ¥7600.00
美元价: 4560.00
产地: 美国(厂家直采)
公司:
产品分类: 聚合物
公司分类: juhewu
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

Overview:

DNAJB1-PRKACA is a chimeric fusion between the catalytic subunit alpha (PRKACA) of protein kinase A and the J-domain of the heat shock protein 40 (DNAJB1). A single segmental genetic deletion in one copy of chromosome 19 combines the first exon of DNAJB1 with exon 2 through 10 of PRKACA and results in the chimeric gene DNAJB1-PRKACA (1). Fusion kinase, DNAJB1-PRKACA is implicated in development of Fibrolamellar Hepatocellular Carcinoma (FL-HCC), thus is a potential oncogenic factor and a candidate drug target for FL-HCC (2).

Gene Aliases:

DNAJB1: Hsp40, DNAJ1PRKACA: PKACA, PPNAD4

Genbank Number:

NM_006145NM_002730

References:

1. Honeyman, J N. et al: Detection of a recurrent DNAJB1-PRKACA chimeric transcript in fibrolamellar hepatocellular carcinoma. Science 343: 1010-1014, 2014. 2. Kastenhuber, E R. et al: DNAJB1–PRKACA fusion kinase interacts with β- and the liver regenerative response to drive fibrolamellar hepatocellular carcinoma. PNAS 14(50): 13076-13084, 2017.

品牌介绍
SignalChem 公司生产和销售创新性的细胞信号研究相关产品。公司专注于生产高纯度的活性重组蛋白,产品广泛应用于基础生物学和药物研究。
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