4000-520-616
欢迎来到免疫在线!(蚂蚁淘生物旗下平台)  请登录 |  免费注册 |  询价篮
主营:主营:活性激酶,信号蛋白,激酶抗体,非活性激酶,活性磷酸酶,生物相关激酶和多肽底物
咨询热线电话
4000-520-616
当前位置: 首页 > 产品中心 > juhewu > Signalchem/EGFR (D770_N771insNPG T790M), Active/10 ug/E10-132TG-10
商品详细Signalchem/EGFR (D770_N771insNPG T790M), Active/10 ug/E10-132TG-10
Signalchem/EGFR (D770_N771insNPG T790M), Active/10 ug/E10-132TG-10
Signalchem/EGFR (D770_N771insNPG T790M), Active/10 ug/E10-132TG-10
商品编号: E10-132TG-10
品牌: Signalchem inc
市场价: ¥6500.00
美元价: 3900.00
产地: 美国(厂家直采)
公司:
产品分类: 聚合物
公司分类: juhewu
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

Overview:

EGFR is the receptor for members of the EGF family and is a transmembrane glycoprotein that has tyrosine kinase activity. Binding of epidermal growth factor to EGFR induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation, differentiation, motility, and cell survival (1). Activation of EGFR triggers mitogenic signaling in gastrointestinal mucosa, and its expression is upregulated in colon cancers and most neoplasms (2). Activation of EGFR triggers activation of the ERK-signaling pathway in normal gastric epithelial and colon cancer cell lines. Inactivation of EGFR with selective inhibitors significantly reduces ERK2 activation, c-fos mRNA expression and cell proliferation.

Gene Aliases:

ERBB, mENA, ERBB1, HER1

Genbank Number:

NM_005228

References:

1. Wang K, et al: Epidermal growth factor receptor-deficient mice have delayed primary endochondral ossification because of defective osteoclast recruitment. J. Biol. Chem. 279: 53848-53856, 2004.2. Kobayashi S, et al: EGFR mutation and resistance of non-small-cell lung cancer to gefitinib. New Eng. J. Med. 352: 786-792, 2005.

品牌介绍
SignalChem 公司生产和销售创新性的细胞信号研究相关产品。公司专注于生产高纯度的活性重组蛋白,产品广泛应用于基础生物学和药物研究。
联络我们
服务热线:4000-520-616
(限工作日9:00-18:00)
QQ :1570468124
手机:18915418616