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商品详细Signalchem/PRKACA(L206R),活性/10 ug/P51-19CG-10
Signalchem/PRKACA(L206R),活性/10 ug/P51-19CG-10
Signalchem/PRKACA(L206R),活性/10 ug/P51-19CG-10
商品编号: P51-19CG-10
品牌: Signalchem inc
市场价: ¥7600.00
美元价: 4560.00
产地: 美国(厂家直采)
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产品分类: 聚合物
公司分类: juhewu
联系Q Q: 3392242852
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商品介绍

Overview:

The catalytic subunit C-alpha of PRKACA is a member of the Ser/Thr protein kinase family and has been assigned to chromosome region 19p13.1 (1). Null mutation in PRKACA leads to early postnatal lethality in the majority of C-alpha knockout mice. Surprisingly, a small percentage of C-alpha knockout mice, although runted, survived to adulthood. In these animals, compensatory increases in C-beta levels occurred in brain whereas many tissues, including skeletal muscle, heart, and sperm, contained less than 10% of the normal PKA activity (2).

Gene Aliases:

PKACA, PPNAD4

Genbank Number:

NM_002730

References:

1. Tasken, K. et al:The gene encoding the catalytic subunit C-alpha of cAMP-dependent protein kinase (locus PRKACA) localizes to human chromosome region 19p13.1. Genomics 36: 535-538, 1996. 2. Skalhegg, BS. Et al: Mutation of the C-alpha subunit of PKA leads to growth retardation and sperm dysfunction. Molec. Endocr. 16: 630-639, 2002.

品牌介绍
SignalChem 公司生产和销售创新性的细胞信号研究相关产品。公司专注于生产高纯度的活性重组蛋白,产品广泛应用于基础生物学和药物研究。
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