Overview:
Set1/Ash2 histone methyltransferase complex subunit ASH2 (ASH2L) is part of MLL complexes, consisting of one of seven Set/MLL proteins (SETA, SETB, MLL1 to 5), ASH2L, RBBP5, WDR5, HDPY-30, and others. Possesses histone methyltransferase activity. Specifically methylates "Lys-4" of histone H3 when the neighboring "Lys-9" residue is not methylated.
Gene Aliases:
ASH2L2
Genbank Number:
BC015936
References:
1. Patel A, et al: On the mechanism of multiple lysine methyla-tion by the human mixed lineage leukemia protein-1 (MLL1) core complex. J Biol Chem. 2009 284(36):24242-56.2. Qi J, et al: Absent, small or homeotic 2-like protein (ASH2L) enhances the transcription of the estrogen receptor α gene through GATA-binding protein 3 (GATA3). J Biol Chem. 2014 289(45):31373-81.
