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当前位置: 首页 > 产品中心 > juhewu > Signalchem/UBLE1A (SAE1) Protein/20 ug/U208-30G-20
商品详细Signalchem/UBLE1A (SAE1) Protein/20 ug/U208-30G-20
Signalchem/UBLE1A (SAE1) Protein/20 ug/U208-30G-20
Signalchem/UBLE1A (SAE1) Protein/20 ug/U208-30G-20
商品编号: U208-30G-20
品牌: Signalchem inc
市场价: ¥4300.00
美元价: 2580.00
产地: 美国(厂家直采)
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产品分类: 聚合物
公司分类: juhewu
联系Q Q: 3392242852
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商品介绍

Overview:

UBLE1A (also known as SAE1) or SUMO1 activating enzyme subunit 1 is involved in regulating protein structure and intracellular localization. SAE1 and UBA2 form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (1). The SAE1/SAE2 dimer functions in SUMO1 activation in a manner analogous to the single E1 ubiquitin-activating enzymes. The SAE2 inactivation may be a therapeutic strategy in MYC-driven cancers (2).

Gene Aliases:

SAE1; SUA1; HSPC140; AOS1; FLJ3091; HSPC140

Genbank Number:

NM_005500

References:

1. Okuma, T. et.al: In vitro SUMO-1 modification requires two enzymatic steps, E1 and E2. Biochem. Biophys. Res. Commun. 254: 693-698, 1999.2. Kessler, J. D. et.al: A SUMOylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis. Science 335: 348-353, 2012.

品牌介绍
SignalChem 公司生产和销售创新性的细胞信号研究相关产品。公司专注于生产高纯度的活性重组蛋白,产品广泛应用于基础生物学和药物研究。
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