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当前位置: 首页 > 产品中心 > juhewu > Signalchem/UBE2R1 Protein/50 ug/U234-30H-50
商品详细Signalchem/UBE2R1 Protein/50 ug/U234-30H-50
Signalchem/UBE2R1 Protein/50 ug/U234-30H-50
Signalchem/UBE2R1 Protein/50 ug/U234-30H-50
商品编号: U234-30H-50
品牌: Signalchem inc
市场价: ¥3200.00
美元价: 1920.00
产地: 美国(厂家直采)
公司:
产品分类: 聚合物
公司分类: juhewu
联系Q Q: 3392242852
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商品介绍

Overview:

UBE2R1 is a member of the ubiquitin-conjugating enzyme family which catalyzes the covalent attachment of ubiquitin to other proteins. UBE2R1 is a part of the large multiprotein complex which is required for ubiquitin-mediated degradation of cell cycle G1 regulators and for the initiation of DNA replication (1). CK2 can phosphorylate CDC34 and UBC3B at corresponding serine residue in the C terminus of each protein. Phosphorylated UBC3B and CDC34 binds specifically to the F-box protein beta-TRCP which results in enhanced degradation of beta-catenin, a substrate of BTRC. CK2-dependent phosphorylation of CDC34 and UBC3B functions by regulating BTRC substrate recognition (2).

Gene Aliases:

E2-CDC34; UBC3; UBCH3; CDC34

Genbank Number:

NM_004359

References:

1. Plon, S. E. et.al: Cloning of the human homolog of the CDC34 cell cycle gene by complementation in yeast. Proc. Nat. Acad. Sci. 90: 10484-10488, 1993.2. Semplici, F. et.al: CK2-dependent phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with beta-TrCP and enhances beta-catenin degradation. Oncogene 21: 3978-3987, 2002.

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