Overview:
The PAD family of enzymes is responsible for the catalysis of arginine-to-citrulline conversion in target proteins.There are 5 mammalian PAD isoforms (PAD1-4,6) that share ~50% sequence homology. Each PAD enzyme has its own typical subcellular localization, tissue distribution and substrate specificity, although no substrate protein has been found so far for PAD6.
Genbank Number:
NM_013358 (PAD1)BC049947 (PAD2)NM_016233 (PAD3)BC025718 (PAD4)NM_207421 (PAD6)
References:
1. Tilvawala, R et. Al: Peptidyl arginine deiminases: detection and finctional analysis of protein citrullination. Curr. Opin. Struct. Biol. 20, 1-11, 2019.2. Clancy K.W. et al., Detection and identification of protein citrullination in complex biological systems. Curr. Opin. Chem. Biol., 30, 1-6, 2016.
