Overview:
Carboxylesterase 2 (CES2) is a member of the carboxylesterase family, which catalyzes the hydrolysis transesterification of various xenobiotic and endogenous substrates with ester, thioester, or amide bonds to detoxify the xenobiotics and activate the prodrugs (1). CES2 is mainly expression in intestine to hydrolyze substrates with a large alcohol group and small acyl group such as aspirin, the anticancer prodrug irinotecan (CPT-11), and flutamide (2). In addition, CES2 is also involved in obesity and fatty liver disease, which is related in lipid metabolism (2).
Gene Aliases:
iCE; CE-2; PCE-2; CES2A1
Genbank Number:
NM_001365405
References:
1. Redinbo, M. R. and P.M. Potter. Mammalian carboxylesterases: from drug targets to protein therapeutics. (2005) Drug Discovery Today, 10:313.2. Lian J., Nelson R., Lehner R. Carboxylesterases in lipid metabolism: from mouse to human. Protein Cell 9:178-195(2018).
