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商品详细Signalchem/Bafilmycin A1/1 mg/V115-905-1000
Signalchem/Bafilmycin A1/1 mg/V115-905-1000
Signalchem/Bafilmycin A1/1 mg/V115-905-1000
商品编号: V115-905-1000
品牌: Signalchem inc
市场价: ¥3200.00
美元价: 1920.00
产地: 美国(厂家直采)
公司:
产品分类: 聚合物
公司分类: juhewu
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

Overview:

**COVID-19 RELATION**Bafilomycin A is a macrolide antibiotic and a highly potent V-ATPase inhibitor. It has been well researched for its role as an inhibitor of the vascular proton ATPases and has been administered to demonstrate the requirement of low endosomal pH for viral uncoating. Bafilomycin A has been actively studied for its role against viruses like influenza A and hepatitis C. Scientists are studying clinical implications of using Bafilomycin A1 against the SARS-CoV-2 virus as it has been documented that theNsp6 and M proteins of SARS-CoV-2 interact with the V1-ATPase subunits.**A vacuolar H+-ATPase inhibitor, IC50 = 0.6-1.5 nM in bovine chromaffin granules (1). Highly selective for V-ATPase over F-ATPases and P-ATPase. Inhibits autophagy by preventing maturation of autophagic vacuoles via inhibition of fusion between autophagosomes and lysosomes (2). Inhibits bone resorption in various models (3). An extremely useful tool for exploring physiological processes regulated by V-ATPase (4).

References:

1. S Gagliardi et al. Curr. Med. Chem. 1999 6:1197 2. A Yamamoto et al. Cell Struct. Funct. 1998 23:33 3. AV Neutzsky-Wulff et al. BMC Musculoskelet. Disord. 2010 11:109 4. T Yoshimori et al. J. Biol. Chem. 2015 290:8039

品牌介绍
SignalChem 公司生产和销售创新性的细胞信号研究相关产品。公司专注于生产高纯度的活性重组蛋白,产品广泛应用于基础生物学和药物研究。
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