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商品详细Signalchem/Captopril/1 g/A51-906-1
Signalchem/Captopril/1 g/A51-906-1
Signalchem/Captopril/1 g/A51-906-1
商品编号: A51-906-1
品牌: Signalchem inc
市场价: ¥900.00
美元价: 540.00
产地: 美国(厂家直采)
公司:
产品分类: 聚合物
公司分类: juhewu
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

Overview:

**COVID-19 RELATION**Captopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). The compound is an effective treatment against high blood pressure and a few types of congestive heart failures. SARS-CoV-2 infects the human cells by using its Spike (S) protein to fuse with the human ACE2 cell receptor. Renin-Angiotensin-Aldosterone System Inhibitors such as Captopril are being investigated for their unconventional therapeutic role in inhibiting SARS-CoV-2/ACE2 fusions as a possible treatment option to solve the COVID-19 crisis.**Angiotensin-converting enzyme (ACE) inhibitor (IC50 = 0.22 μM) (1). Also inhibits the bifunctional Zn2+-containing leukotriene A4 hydrolase/aminopeptidase (LTA4 hydrolase) reversibly and competitively (Ki = 6.0 &muM for leukotriene B4 formation and Ki = 60 nM for L-lysine-p=nitroanilide) (2). Displays vasodilatory and antihypertensive effects in vivo. Clinically useful antihypertensive agent.

References:

1. DW Cushman et al. Nat. Med. 1999 5:11102.2. L Orning et al. J. Biol. Chem. 1991 266:16507

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SignalChem 公司生产和销售创新性的细胞信号研究相关产品。公司专注于生产高纯度的活性重组蛋白,产品广泛应用于基础生物学和药物研究。
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