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商品详细Signalchem/Chloroquine phosphate/1 g/C119-905-1
Signalchem/Chloroquine phosphate/1 g/C119-905-1
Signalchem/Chloroquine phosphate/1 g/C119-905-1
商品编号: C119-905-1
品牌: Signalchem inc
市场价: ¥900.00
美元价: 540.00
产地: 美国(厂家直采)
公司:
产品分类: 聚合物
公司分类: juhewu
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

Overview:

**COVID-19 RELATION**Chloroquine Phosphate is the phosphate salt of chloroquine, a quinoline compound. The compound is used as an effective treatment against malaria caused by Plasmodium falciparum. Researchers are actively investigating this compound against the SARS-CoV-2 and have documented that that chloroquine phosphate may control the infection by promoting a virus-negative conversion and shortening the disease. The molecular studies suggested multiple potential mechanisms employed by the compound, including inhibiting viral endocytosis; limiting inflammatory response, and binding ofSigma 1 receptor to the SARS-CoV-2 Nsp6 protein.**Antimalarial drug. Inhibits autophagy in a variety of cell lines (1). Induces cell death in breast cancer cell lines and displays antitumor and antimetastatic activity in mouse models of breast cancer (2). Eliminates cancer stem cells via deregulation of Jak2 and DNMT1 (3). Displays synergy when combined with Raf inhibitor, vemurafenib, in brain tumors (4). Cell permeable and active in vivo.

References:

1. HB Frieboes et al.JOP 2014 15:1892. PD Jiang et al. Biomed. Pharmacother. 2010 64:6093. DS Choi et al. Stem Cells. 2014 32:23094. JM Mulcahy Levy et al. Cancer Discov. 2014 4:773

品牌介绍
SignalChem 公司生产和销售创新性的细胞信号研究相关产品。公司专注于生产高纯度的活性重组蛋白,产品广泛应用于基础生物学和药物研究。
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