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商品详细Signalchem/Niclosamide/1 g/S54-900-1
Signalchem/Niclosamide/1 g/S54-900-1
Signalchem/Niclosamide/1 g/S54-900-1
商品编号: S54-900-1
品牌: Signalchem inc
市场价: ¥900.00
美元价: 540.00
产地: 美国(厂家直采)
公司:
产品分类: 聚合物
公司分类: juhewu
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

Overview:

**COVID-19 RELATION**Niclosamide is an active chlorinated salicylanilide compound, with anthelmintic and potential antineoplastic activity used to treat tapeworm infections but has a broad spectrum of therapeutic potential. Scientists are investigating niclosamide and how it inhibits CoV replication and viral antigen synthesis by investigating the various mode of actions such as regulating the mTORC1 pathway,members of which may be interacting with SARS-CoV-2 N and Orf8 proteins; and reducing replication of related coronavirus MERS-CoV via SKP2 inhibition.**Reversibly inhibits Mtorc1 signaling and stimulates autophagy (1). Inhibits activation and nuclear translocation of STAT3 selectively over STAT1 and STAT5. Inhibits transcription of STAT3 target genes and induces cell cycle arrest and apoptosis in cells with constitutively active STAT3 (2). Reverses radioresistance in human lung cancer cells and xenografts (3).

References:

1. AD Balgi et al. PloS One 2009 4:e71242. X Ren et al. ACS Med. Chem. Lett. 2010 1:4543. Y Shuo et al. Mol. Cancer Ther.2013 13:606

品牌介绍
SignalChem 公司生产和销售创新性的细胞信号研究相关产品。公司专注于生产高纯度的活性重组蛋白,产品广泛应用于基础生物学和药物研究。
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