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商品详细Signalchem/Nitazoxanide/10 mg/P312-905-10
Signalchem/Nitazoxanide/10 mg/P312-905-10
Signalchem/Nitazoxanide/10 mg/P312-905-10
商品编号: P312-905-10
品牌: Signalchem inc
市场价: ¥1100.00
美元价: 660.00
产地: 美国(厂家直采)
公司:
产品分类: 聚合物
公司分类: juhewu
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

Overview:

**COVID-19 RELATION** Nitazoxanide is a broad-spectrum synthetic benzamide compound that is used as medicine for the treatment of various helminthic, protozoal, and viral infections. In-vitro analysis suggests that this compound inhibits replication of many members of the coronavirus family including MERS-Cov, BCoV, HECoV, and improves clinical outcomes by suppressing the overproduction of pro-inflammatory cytokines which is observed in patients with coronavirus infection. The clinical implications of this compound on SARS-CoV-2 is under investigation at the moment. ** Nitazoxanide is a clinically useful antiparasitic agent (1). It has since been repurposed as a broad-spectrum antiviral agent that is active against many RNA and DNA viruses including influenza, hepatitis B and C, RSV, coronavirus, dengue, and others (2). Its antiparasitic activity is believed to be due to inhibition of pyruvate:ferredoxin/flavodoxin oxidoreductases (3). Antiviral activity involves activation of protein kinase activated by double-stranded RNA (PKR) leading to phosphorylation of eukaryotic initiation factor 2 alpha (eIF2α) (4). Nitazoxanide has also been found to inhibit Wnt signaling independent of adenomatous polyposis coli (APC), targeting peptidyl arginine deiminase 2 (PAD2) resulting in increased citrullination of β-catenin (5).

References:

1. CA White Expert Rev. Anti. Infect. Ther. 2004 2:432. J-F Rossignol Antiviral Res. 2014 110:943. PS Hoffman et al. Antimicrob. Agents Chemother. 2007 51:8684. M Elazar et al. Gastroenterology 2009 137:18275. Y Qu et al. Nat. Chem. Biol. 2018 14:94

品牌介绍
SignalChem 公司生产和销售创新性的细胞信号研究相关产品。公司专注于生产高纯度的活性重组蛋白,产品广泛应用于基础生物学和药物研究。
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