Overview:

IFN-gamma encodes the ligand-binding chain (alpha) of the gamma interferon receptor which is a heterodimer of IFNGR1 and IFNGR2 and IFNGR1 is associated with susceptibility to Helicobacter pylori infection. IFN-gamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity (1). IFN-gamma is also a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection. IFNG is a regulator of hematopoietic stem cells during homeostasis and under conditions of infectious stress (2).

Gene Aliases:

IFNG; IFG; IFI

Genbank Number:

NP_000610.2

References:

1. Shankaran, V. et.al: IFN-gamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity. Nature 410: 1107-1111, 2001.2. Baldridge, M. T. et.al: Quiescent haematopoietic stem cells are activated by IFN-gamma in response to chronic infection. Nature 465: 793-797, 2010.