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商品详细Signalchem/Alpha-synuclein Protein/50 ug/S22-30H-50
Signalchem/Alpha-synuclein  Protein/50 ug/S22-30H-50
Signalchem/Alpha-synuclein Protein/50 ug/S22-30H-50
商品编号: S22-30H-50
品牌: Signalchem inc
市场价: ¥3200.00
美元价: 1920.00
产地: 美国(厂家直采)
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商品介绍

Overview:

Alpha-synuclein is a member of the synuclein family which also includes beta- and gamma-synuclein. These proteins are abundantly expressed in the brain and alpha- and beta-synuclein selectively inhibit phospholipase D2 which is a highly conserved protein that is also abundant in neurons, especially presynaptic terminals (1). Alpha-synuclein gene is not a major risk factor in familial Parkinson disease (2). Alpha-synuclein may serve to integrate pre-synaptic signaling and membrane trafficking and Alpha-synuclein peptides are a major component of amyloid plaques in the brains of patients with Alzheimer"s disease.

Gene Aliases:

NACP; PARK1; PARK4; PD1; SNCA

Genbank Number:

NM_000345

References:

1. Giasson, B. I. et.al: Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions. Science 290: 985-989, 2000.2. Markopoulou, K. et.al: Greek-American kindred with autosomal dominant, levodopa-responsive Parkinsonism and anticipation. Ann. Neurol. 38: 373-378, 1995.

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