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商品详细Signalchem/4EBP1 Protein/50 ug/E35-54H-50
Signalchem/4EBP1 Protein/50 ug/E35-54H-50
Signalchem/4EBP1 Protein/50 ug/E35-54H-50
商品编号: E35-54H-50
品牌: Signalchem inc
市场价: ¥8700.00
美元价: 5220.00
产地: 美国(厂家直采)
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产品分类: 聚合物
公司分类: juhewu
联系Q Q: 3392242852
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商品介绍

Overview:

4EBP1 is a member of a family of translation repressor proteins that directly interact with eukaryotic translation initiation factor 4E (EIF4E). Interaction of 4EBP1 with EIF4E inhibits the multisubunit complex that recruits 40S ribosomal subunits to the 5" end of mRNAs thereby leading to repression of translation. Insulin treatment of adipose cells increases the phosphorylation of 4EBP1 and leads to reduced interaction of 4EBP1 with EIF4E (1). 4EBP1 is expressed in most tissues, with highest levels seen in adipose tissue, pancreas, and skeletal muscle (2).

Gene Aliases:

BP-1, EIF4EBP1, PHAS-I, MGC4316

Genbank Number:

NM_004095

References:

1.Pause, A. et al: Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5-prime-cap function. Nature 371: 762-767, 1994.2.Tsukiyama-Kohara, K. et al: Tissue distribution, genomic structure, and chromosome mapping of mouse and human eukaryotic initiation factor 4E-binding proteins 1 and 2. Genomics 38: 353-363, 1996.

品牌介绍
SignalChem 公司生产和销售创新性的细胞信号研究相关产品。公司专注于生产高纯度的活性重组蛋白,产品广泛应用于基础生物学和药物研究。
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