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当前位置: 首页 > 产品中心 > juhewu > Signalchem/Tau-441 (T217A) Protein/50 ug/T08-56ON-50
商品详细Signalchem/Tau-441 (T217A) Protein/50 ug/T08-56ON-50
Signalchem/Tau-441 (T217A) Protein/50 ug/T08-56ON-50
Signalchem/Tau-441 (T217A) Protein/50 ug/T08-56ON-50
商品编号: T08-56ON-50
品牌: Signalchem inc
市场价: ¥6720.00
美元价: 4032.00
产地: 美国(厂家直采)
公司:
产品分类: 聚合物
公司分类: juhewu
联系Q Q: 3392242852
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商品介绍

Overview:

Tau-441 or Tau-F is a member of the Tau family of proteins which function to stabilize the microtubules by binding to them. Tau proteins are subject to phosphorylation and this phenomenon regulates the association of the Tau protein with the microtubules (1). Deposits of Alzheimer"s disease AD-associated proteins, such as hyperphosphorylated Tau, as well as other shared misfolded proteins, such as, β-amyloid precursor protein (βAPP), ubiquitin, and various chaperones and protein kinases are thought to play a pathologic role in the cognitive decline and muscular failure. Malfunctioning of Tau proteins is associated with microtubules disintegration and collapsing of the neuronal transport system (2).

Gene Aliases:

Tau-F, (N2R4), Tau-4, MAPT, MSTD; PPND; DDPAC; MAPTL; MTBT1; MTBT2; FTDP-17; FLJ31424; MGC138549

Genbank Number:

P10636-8

References:

1. Zilka, N., et al.Truncated tau from sporadic Alzheimer"s disease suffices to drive neurofibrillary degeneration in vivo. FEBS Lett. 2006; 508: 3582-3588.2. Rial, A. et al: Calcium Dyshomeostasis in -Amyloid and Tau-bearing Skeletal Myotubes. J. Biol. Chem., 2004; 279: 3524-53532.

品牌介绍
SignalChem 公司生产和销售创新性的细胞信号研究相关产品。公司专注于生产高纯度的活性重组蛋白,产品广泛应用于基础生物学和药物研究。
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