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商品详细Signalchem/ARPP19蛋白质/200微克/A76-54G-200
Signalchem/ARPP19蛋白质/200微克/A76-54G-200
Signalchem/ARPP19蛋白质/200微克/A76-54G-200
商品编号: A76-54G-200
品牌: Signalchem inc
市场价: ¥3200.00
美元价: 1920.00
产地: 美国(厂家直采)
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产品分类: 聚合物
公司分类: juhewu
联系Q Q: 3392242852
电话号码: 4000-520-616
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商品介绍

Overview:

ARPP19, cAMP-regulated phosphoprotein 19, is specifically phosphorylated at Ser-62 during mitosis by MASTL, also known as the Greatwall kinase. The phos-phorylation of ARPP19 leads to inactivation of PP2A through its interaction with PR55-delta, which is essential in maintaining the activity of CDK1/cyclin B1 and promoting mitotic G2/M transition (1). Significant reduction of ARPP-19 was observed in brains of Alzheimer’s disease and Down syndrome (2). ARPP-19 was also found to contribute to tumor growth in hepatocellular carcinoma and papillary carcinoma (3).

Gene Aliases:

ARPP-16; ARPP-19; ARPP16; ENSAL

Genbank Number:

NM_006628

References:

1. Gharbi-Ayachi, A., et al. The substrate of Greatwall kinase, Arpp19, controls mitosis by inhibiting protein phosphatase 2A. Science. 330(6011): 1673-1677, 2010.2. Kim, S. H., et al.Decreased levels of ARPP-19 and PKA in brains of Down syndrome and Alzheimer"s disease. J Neural Transm Suppl. 61: 263-272, 2001.3. Song, H., et al. Increased ARPP-19 expression is associated with hepatocellular carcinoma. Int J Mol Sci. 16(1): 178-192, 2014.

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SignalChem 公司生产和销售创新性的细胞信号研究相关产品。公司专注于生产高纯度的活性重组蛋白,产品广泛应用于基础生物学和药物研究。
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